Theorizing China-world integration: sociospatial reconfigurations and the modern silk roads

This paper develops a spatial perspective to examine the nature of China’s transnational influence, focusing on the implications of the Belt and Road Initiative (BRI) for international relations. Drawing upon political economy, regional studies and critical geopolitics, we argue that the most interesting puzzle concerning the BRI pertains to the ongoing reconfigurations of political space. Contemporary sociospatial reconfigurations as analyzed through a multidimensional framework offer key insights into the operations and the extent of China’s growing global power in general and with respect to the BRI in particular. We draw on a broad range of materials such as maps, Chinese academic and policy discourse as well as observations about corridor projects to theorize a) how the spatiality of global and regional connectivity is reconfigured through the process of China’s integration with the world; and b) how corridorization as a dominant physical and ideational process shapes Chinese investment projects and reconfigures state spatiality along the BRI. The results indicate that the main territorial pattern is not the nation or the region but the corridor. Furthermore, expansionist and unidirectional stories of China’s growing power overlook the local encounters and negotiations necessary for infrastructure projects to succeed. In addition, China’s economic statecraft is contextualized within the ongoing post-financial crisis political-economic restructuring of territories, places, and scales within the global capitalist system

The Unbearable Lightness of International Relations : Technological Innovations, Creative Destruction and Assemblages

How could one oversee the monumental modern landscape that has been created by over 250 years of continuous technological innovations? Notwithstanding a few students of international relations who have insisted in taking notice, technology has remained an exotic subject matter in International Relations theory (IR). While the interest in technologies is recently growing most IR scholarship remains silent: the fact that we live in a fully integrated and interconnected technological world is absent from textbooks and introductions to IR. Neither exists theoretical approaches and paradigmatic debates that are concerned with technologies; nor a specific intra-disciplinary subfield. Against this background, this book explores how technological innovations could be theorized and integrated into IR theories. Revisiting the inroads of theoretical approaches to technologies, it highlights the lightness of IR scholarship. I argue that the general framework of IR is untenable because it looks at the world as if there were no materials or rather, as if the pervasive presence of artifacts and infrastructures would have no theoretical relevance for conceptualizing and examining world politics. Drawing on ontological and epistemological understandings from anthropology, innovation economics, and science and technology studies, I take issue with the philosophical foundations of the discipline. The notions, concepts and practices, which ultimately sustain and legitimize this lightness, are interrogated. It is shown that the neglect of technological innovation does not merely result from coincidental intellectual moves. It is rather the result of the “Cartesian complex” – the foundational commitment that renders IR a purely social science that deliberately excludes non-humans and hybrid material modes of agency. A radical refashioning is therefore required to the extent to which IR theory aims to accommodate the highly complex and elusive subject matter of technological innovations. This conceptual catharsis does not primarily touch upon epistemological concerns. What is at stake is the limitation of ontological parameters that sustain IR theories. To make sense of the messy technological landscapes, the material agency, and the technologically mediated practices, the prevailing logocentric wisdom needs to be transcended. Against premature metaphysical closure, this book thus contributes to the task of ontological expansion. Firstly, it develops an alternative meta-theoretical foundation coined “explorative realism”. A new meta-theoretical matrix is proposed that renders wider ontological parameters intelligible. Especially, the “double-mixed” zone encourages ontological expansion via notions of heterogeneous agency and process philosophy. This implies that IR scholars avoid treating time, space, knowledge, artificial objects, and built environments as constants but as always croproduced. A coproductive commitment opens up new empirical issues and concerns as well as radically different theoretical puzzles. It also implies overcoming Cartesian dualism, abandoning intentionality-based notions of agency, and forgetting the “level of analysis” assumption. Secondly, this book advances a theoretical toolbox consisting of the interrelated concepts of “assemblages” and “creative destruction”. The former term signifies actor-networks entailing both humans and non-humans. The latter captures the ways in which technological innovations alter or destabilize assemblages across all levels through a process of translation. This theoretical vocabulary also reconceptualizes the meaning of “power”, “authority” with reference to technological innovations. Three open-ended classifications and three models of creative destruction enable the mapping of magnitudes of translations, the changing size and topologies of assemblages and the shifting power and authority. These efforts to theorize technological innovations, then, support empirical research on global transformations and processes of emergence with a set of conceptual tools that allows locating and systematizing cases, puzzles, and scales in relation to assemblages. The study of technological innovations is productive and challenging. It leads to the discovery of novel empirical landscapes and inspires a creative questioning of IR’s foundations. As such, while responding to the stunning absence of theoretical approaches in IR that make sense of technological innovations, this study contributes to the articulation of both a post-international and post-Cartesian version of IR

Infrastructuring Cyberspace: Exploring China’s Imaginary and Practices of Selective Connectivity

Connectivity and fragmentation coexist as two interlinked discourses on the relationship between infrastructures and societies. In response to the Digital Silk Road initiated by the Chinese government, Chinese companies have built numerous digital infrastructures globally. Simultaneously, China's government seeks to strengthen domestic internet governance through laws and administrative regulations, such as the Cyber Security Law. This paper utilises the interpretive framework of "sociotechnical imaginaries" to explore the controversial tension between digital fragmentations and connectivity in cyberspace along technical, institutional and political dimensions. Scrutinising two cases studies - New IP and smart city - the study finds that China's approach to infrastructuring cyberspace can be best understood as selective connectivity. China not only integrates into global cyber infrastructures to enhance its technological and regulatory capabilities, but also attempts to reshape global cyberspace governance to strengthen its political structures and enhance digital autonomy, seeking a balance between digital sovereignty, regime security and economic development. However, selective connectivity brings its own complexities and drawbacks

Dependence of aptamer activity on opposed terminal extensions : improvement of light-regulation efficiency

Aptamers that can be regulated with light allow precise control of protein activity in space and time and hence of biological function in general. In a previous study, we showed that the activity of the thrombin-binding aptamer HD1 can be turned off by irradiation using a light activatable "caged" intramolecular antisense-domain. However, the activity of the presented aptamer in its ON state was only mediocre. Here we studied the nature of this loss in activity in detail and found that switching from 5'- to 3'-extensions affords aptamers that are even more potent than the unmodified HD1. In particular we arrived at derivatives that are now more active than the aptamer NU172 that is currently in phase 2 clinical trials as an anticoagulant. As a result, we present light-regulatable aptamers with a superior activity in their ON state and an almost digital ON/OFF behavior upon irradiation

Early detection of virus infections in potato by aphids and infrared remote sensing

Potato is one of the most important crops worldwide. In recent years, breeding and advances in crop protection have made it possible to increase potato yield and production despite decreasing area harvested. Nonetheless problems with pests are still prevalent and can destroy big parts of the annual harvest. One of the mayor problems in potatoes are viruses, due to the lack of chemical control. The Potato Leaf Rolle Virus (PLRV) and the Potato Virus Y (PVY) are the most threatening viral diseases. Both are transmitted with aphids. While it has been shown, that the persistent virus PLRV attracts aphids through altered volatiles in potatoes, this proof was lacking for the non- persistent virus PVY. Our results of aphid olfactory response have shown that the odors of potato cultivars expressing a great amount of symptoms when infected with PVY attracted significantly more aphids than the odors from virus fee plants. However, only in early growing stages of the plants, PVY infected potatoes were more attractive for aphids. Viral diseases are also transferred in vegetative propagation with seed tubers. The plants derived from these infected tubers are the source for new virus infections in the field. Unfortunately, up to now, virus detection in plants is limited to serological (ELISA) and molecular (PCR) methods, which are destructive and time consuming. Early detection of PVY infected plants and their removal from the field is the most important measure to stop/reduce virus distribution by aphids. We demonstrated that mid- infrared imaging can be used to detect virus infections in early growing stages of plants before symptoms are visible to the human eye. The diagnosis of viral infections with infrared techniques became more accurate with the age of examined plants. Our studies indicate that remote sensing with mid infrared cameras can be used to identify PVY infected plants in a growing stage in which aphid attraction via odors occurs. Mid infrared sensing can therefore be used to detect infected plants before aphids arrive in the field

Die Gestaltung der Globalität. Schlüsselwörter der sozialen Ordnung (I) = The design of globality. Keywords of the social order (I). ZEI Discussion Paper C211, 2012

Since 2009, ZEI is engaged in a research project titled "Shaping Globality". Following methodological and conceptual work, the scholars engaged in this project have begun to reflect the consequences of the "global turn" on key notions of social order. The new ZEI Discussion Paper brings together several scholarly papers on key notions of social order under the conditions of globality, written by academics of Bonn University: space (Ruth Knoblich/Robert Meyer), norm (Andreas Marchetti), world government (Christian Schwermann) and knowledge (Maximilian Mayer). The ZEI Discussion Paper is edited by Ludger Kühnhardt and Tilman Mayer

Early lire imprints the hierarchy of T cell clone sizes

The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in detail, it is unknown how a lifetime of exposures to many antigens collectively shape the immune repertoire. Here, using mathematical modeling and statistical analyses of T cell receptor sequencing data, we develop a quantitative theory of human T cell dynamics compatible with the statistical laws of repertoire organization. We find that clonal expansions during a perinatal time window leave a long-lasting imprint on the human T cell repertoire, which is only slowly reshaped by fluctuating clonal selection during adult life. Our work provides a mechanism for how early clonal dynamics imprint the hierarchy of T cell clone sizes with implications for pathogen defense and autoimmunity

Early life imprints the hierarchy of T cell clone sizes

The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in detail, it is unknown how a lifetime of exposures to many antigens collectively shape the immune repertoire. Here, through mathematical modeling and statistical analyses of T cell receptor sequencing data we demonstrate that clonal expansions during a perinatal time window leave a long-lasting imprint on the human T cell repertoire. We demonstrate how the empirical scaling law relating the rank of the largest clones to their size can emerge from clonal growth during repertoire formation. We statistically identify early founded clones and find that they are indeed highly enriched among the largest clones. This enrichment persists even after decades of human aging, in a way that is quantitatively predicted by a model of fluctuating clonal selection. Our work presents a quantitative theory of human T cell dynamics compatible with the statistical laws of repertoire organization and provides a mechanism for how early clonal dynamics imprint the hierarchy of T cell clone sizes with implications for pathogen defense and autoimmunity.Comment: 8 pages, 4 figures + 27 pages supplement with 20 figure

Analyse und Darstellung wesentlicher Bestandteile von Projektabwicklungensformen im Bauwesen

Bauprojekte sind geprägt durch Entscheidungen, die im Verlaufe des Projektes getroffen werden müssen. Zu Beginn eines Projektes muss die passende Vergabeform gewählt werden. Nach der Auswahl der passenden Auftragsnehmer müssen Verträge verhandelt und die dafür passenden Bauvertragsarten ausgewählt werden. Die Projektorganisation wird zum Teil durch den gewählten Bauvertrag mitbestimmt. Ein Bauprojekt lässt sich somit nicht auf eine Bauvertragsart allein reduzieren. Es müssen sämtliche Aspekte der sogenannten Projektabwicklung beachtet werden. Der folgende Beitrag gibt einen Überblick zu möglichen Elementen der Projektabwicklung. Dazu werden die gängigen Vergabe-, Projektorganisationsformen und Bauvertragsarten als wesentliche Aspekte der Projektabwicklung vorgestellt und mögliche Projektabwicklungsformen, als Kombination der Projektabwicklungsaspekte, entwickelt bzw. dargestellt

Automation, globalization and vanishing jobs: a labor market sorting view

We show, theoretically and empirically, that the effects of technological change associated with automation and offshoring on the labor market can substantially deviate from standard neoclassical conclusions when search frictions hinder efficient assortative matching between firms with heterogeneous tasks and workers with heterogeneous skills. Our key hypothesis is that better matches enjoy a comparative advantage in exploiting automation and a comparative disadvantage in exploiting offshoring. It implies that automation (offshoring) may reduce (raise) employment by lengthening (shortening) unemployment duration due to higher (lower) match selectivity. We find empirical support for this implication in a dataset covering 92 occupations and 16 sectors in 13 European countries from 1995 to 2010